Timur Tsintsadze,
PhD (biophysics)
tt@serv.biph.kiev.ua


  • Publications
  • Setups:

    • Date of birth: July 21,1970
    Department of Cellular Membranology
    Bogomoletz Institute of Physiology
    Bogomoletz 4, 01024, Kiev
    Ukraine
    Tel.(Fax): +380 44 293 2142
    e-mail: tt@serv.biph.kiev.ua

    Institutional Affiliations:

    1988 - 1994 Undergraduate student at the Moscow Institute of Physics and Technology (MIPT)
    1994 - 1997 Graduate student in Kiev Bogomoletz Institute of Physiology (BIPH)
    1997 - ….. Researcher, Bogomoletz Institute of Physiology, Kiev, Ukraine.

    Fields of interest and research areas:
    Electrophysiology, including investigation of voltage-gated channels ( Ca2+,K+,Na+ ) and ligand-gated channels ( NMDA, non NMDA ) in slices and isolated cells of hippocampus, cerebelum and talamus. Ca2+ measurements using technique fluorescent probes.

    Area of expertise: synaptic plasticity, Hippocampus, Glutamate, adenosine, metabotropic receptors, Ishaemia.

    Awards:
    1. International Travel Fellowship at the Society’s 2001 Annual Meeting
    2. IBRO Scholarship Against Brain-Drain, 2000
    3. IBRO Scholarship Against Brain-Drain, 2001

    Participation:
    1. 2001-2005 Research grant HHMI-55000322 “The properties of ATP-mediated synaptic transmission in the rat hippocampus”. 400,000 USD
    2. 2000-2002 Research grant INTAS-99-01147 “Purinergic modulation of synaptic transmission in central and peripheral nervous system” (Co-ordinator Prof. F. Edwards). 89,400 ECU.
    3. 1995-2000 Research grant HHMI-75195-48001 “Modulation of calcium channels: implication for the excitatory synaptic transmission in hippocampus”. 160,000 USD
    4. 1998-2001 Research grant INTAS-96-1493 “NMDA receptor-mediated positive feedback in excitatory input to CA1 pyramidal neurons: electrophysiological and pharmacological approach to ischemia and epilepsy” (Co-ordinator Prof. U. Heinemann) 60,000 ECU
    5. 1996 CEEC/NIS joint research project (NF 7UKPJ048607) entitled “Separate regulation of NMDA and non-NMDA components of the excitatory synaptic transmission in hippocampus: possible role of various endogenous agonists” supported by Swiss National Science Foundation. 40,000 SFr.
    Teaching:

    IBRO summer shool 2001 Tihany, Hungary IBRO
    Publications
    1. Lozovaya N, Melnik S, Tsintsadze T, Grebenyuk S, Kirichok Y, Krishtal O. Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density. Brain Res. 2004 Jun 18;1011(2):195-205.

    2. Lozovaya NA, Grebenyuk SE, Tsintsadze TS, Feng B, Monaghan DT, Krishtal O. Extrasynaptic NR2B and NR2D subunits of NMDA receptors are shaping "superslow" afterburst EPSC in hippocampus. J Physiol. 2004 May 14

    3. Grebenyuk SE, Lozovaya NA, Tsintsadze TS, Krishtal OA. Post-synaptic N-methyl-d-aspartate signalling in hippocampal neurons of rat: spillover increases the impact of each spike in a short burst discharge. Neurosci Lett. 2004 May 6;361(1-3):60-3.

    4. Krishtal O, Lozovaya N, Fisunov A, Tsintsadze T, Pankratov Y, Kopanitsa M, Chatterjee SS. Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum. Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S74-82.

    5. Krishtal O, Kirichok Y, Tsintsadze T, Lozovaya N, Loesel W, Arndts D. New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons. Neuropharmacology. 2001;40(2):233-41.

    6. Fisunov A, Lozovaya N, Tsintsadze T, Chatterjee S, Noldner M, Krishtal O. Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons. Pflugers Arch. 2000 Jul;440(3):427-34.

    7. Tsintsadze T, Lozovaya N, Klishin A, Krishtal O. NMDA receptor-mediated synapses between CA1 neurones: activation by ischaemia. Neuroreport. 1996 Nov 4;7(15-17):2679-82.

    8. Klishin A, Tsintsadze T, Lozovaya N, Krishtal O. Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca(2+)-dependent activation by blocking A1 adenosine receptors. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12431-5.

    9. Lozovaya, N., Tsintsadze, T., Kopanitsa, M., Boychuk, Y. and Krishtal, O.(1997) Increase of the contribution of NMDA-receptors into synaptic transmission in CA1 area of rat hippocampus after short hypoxic-aglycaemic episods.Neurophysiology, Vol 29, 1.

    10. Kirichok,Y.V., Boychuk,Y.A., Kopanitsa,M.V., Tsintsadze,T.S., Lozovaya,N.A., and Krishtal,O.A.(2000) Effects of mibefradil on synaptic transmission in the hippocampus and on voltage-dependent currents in isolated hippocampal and thalamic neurons of the rat. Neurophysiology 32, 12-16

    11. Tsintsadze,T.S., Lozovaya,N.A., and Krishtal,O.A.(2001) Effects of long-term hypoxia/hypoglycemia on synaptic transmission between the CA3 and CA1 zones in rat hippocampal slices. Neurophysiology 33, 365-371