Name: Lozovaya Natalia Alekseevna
Date of Birth: August 8, 1965
Place of Birth: Kyiv, UKRAINE
Citizenship: UKRAINE

Mailing Address: Bogomoletz Institute of Physiology, Bogomoletz Str.4, Kyiv, 01024, Ukraine
Telephone: (380) 44 256 25 28 (office)
Fax: (380) 44 256 25 90
E-mail: nl@serv.biph.kiev.ua

Publications

Current Affiliation:
Associate Professor, leading scientific researcher, Deputy Head of the Department of Cellular Membranology, Bogomoletz Institute of Physiology,

  • Bogomoletz Institute of Physiology, Kiev, Ukraine
  • International Centre of Molecular Physiology, Kiev, Ukraine

Dissertations:
        2002 Dr.Sci. Thesis (speciality Physiology), Bogomoletz Institute of Physiology, Kyiv, Ukraine. Dissertation: “The role of the extrasynaptic NR2B and NR2D subunits of NMDA receptors in the shaping of afterburst EPSC in hippocampus”.
        1992 PhD Thesis (speciality Biophysics), Bogomoletz Institute of Physiology, Kyiv, Ukraine. Dissertation: “Modulation of acetylcholine receptors-mediated current and fast transient outward K+ current in Lymnaea neurones by intracellular ATP”.

INSTITUTIONAL AFFILIATIONS:
Since 2002 Associate Professor, Deputy Head of the Department of Cellular Membranology, Bogomoletz Institute of Physiology.
1994-2002 - Senior scientists Department of Cellular Membranology, Bogomoletz Institute of Physiology.
1991-1993 - Post-Doctoral Fellow in the Department of Cellular Membranology, Bogomoletz Institute of Physiology, Kiev, Ukraine.
1987-1991 - PhD student, Institute of Biophysics, Puschino, Russian Academy of Sciences.
1982-1986 - Shevchenko State University, Kiev, Ukraine, Diploma about high education with honours. Major: Biophysics.

Fellowship:
         1993-1994 - Max-Plank scholarship, Max-Plank Institute of Brain Research, Frankfurt-on-Main, Germany.

PHARMACEUTICAL RESEARCH & DEVELOPMENT (R & D) ACTIVITY:
         Collaboration with several European pharmaceutical companies on the development of methodology and technology to study specific drugs.

IC-VEC Limited - Jul, 2005 - principal investigator R & D agreement

S elected publication with pharmaceutical companies:
         Krishtal, O., Lozovaya, N., Fisunov, A., Tsintsadze, T., Pankratov, Y., Kopanitsa, M., & Chatterjee, S. S. (2001b). Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum. Pharmacopsychiatry 34 Suppl 1, S74-S82.
         Fisunov, A., Lozovaya, N., Tsintsadze, T., Chatterjee, S., Noldner, M., & Krishtal, O. (2000). Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons. Pflugers Arch. 440, 427-434.
         Krishtal, O., Kirichok, Y., Tsintsadze, T., Lozovaya, N., Loesel, W., & Arndts, D. (2001a). New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons. Neuropharmacology 40, 233-241.

Techniques for evaluation of substances neuroprotective properties:

  1. Patch-clamp screening and pharmacological profiling;
  2. animal models for ischemia;
  3. brain slice models for study of epilepsy and ischemia;

Academic honours
1995, 1997 International Soros Science Education Programme (ISSEP) Scholarship
1999 By a contest nominated for participation in Scientia Europea 4.
2002 IBRO Scholarship against BrainDrain
2003 State Prise of Ukraine

List of Publications:

  1. Lozovaya, N. A., Grebenyuk, S. E., Tsintsadze, T. S., Feng, B., Monaghan, D. T., & Krishtal, O. A. (2004). Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. J.Physiol 558, 451-463.

  2. Blumenstein, Y., Maximyuk, O. P., Lozovaya, N., Yatsenko, N. M., Kanevsky, N., Krishtal, O., & Dascal, N. (2004). Intracellular Na+ inhibits voltage-dependent N-type Ca2+ channels by a G protein betagamma subunit-dependent mechanism. J.Physiol 556, 121-134.[full text]

  3. Grebenyuk, S. E., Lozovaya, N. A., Tsintsadze, T. S., & Krishtal, O. A. (2004). Post-synaptic N-methyl-d-aspartate signalling in hippocampal neurons of rat: spillover increases the impact of each spike in a short burst discharge. Neurosci.Lett. 361, 60-63.

  4. Lozovaya, N., Melnik, S., Tsintsadze, T., Grebenyuk, S., Kirichok, Y., & Krishtal, O. (2004). Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density. Brain Res. 1011, 195-205.

  5. Lozovaya, N. & Miller, A. D. (2003). Chemical Neuroimmunology: health in a nutshell bidirectional communication between immune and stress (limbic-hypothalamic-pituitary-adrenal) systems. Chembiochem. 4, 466-484.

  6. Maximyuk, O., Khmyz, V., Lozovaya, N., Dascal, N., & Krishtal, O. (2002). Na+ influx inhibits neuronal Ca2+ channels. Neurophysiology (Kiev) 34, 182-183.

  7. Maximyuk, O., Lozovaya, N. A., Kopanitsa, M. V., & Krishtal, O. A. (2002). G-protein inhibition of N- and P/Q-type calcium channels. Biologicheskie Membrany (Russia) 19, 42-48.

  8. Melnik, S., Lozovaya, N., Tsintsadze, T., Grebenyuk, S., & Krishtal, O. (2002). Glutamate postsynaptic receptors under the cap: strictly limited access to receptors in the postsynaptic density by non-synaptically released glutamate. Neurophysiology (Kiev) 34, 102-105.

  9. Fisunov, A., Lozovaya, N., Tsintsadze, T., Yatsenko, N. M., Chatterjee, S., & Krishtal, O. (2001). Modulating action of hyperforin on the P-Type calcium channels in the membranes of rat cerebellar Purkinje neurons. Neurophysiology (Kiev) 33, 5-10.

  10. Krishtal, O., Kirichok, Y., Tsintsadze, T., Lozovaya, N., Loesel, W., & Arndts, D. (2001). New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons. Neuropharmacology 40, 233-241.

  11. Krishtal, O., Lozovaya, N., Fisunov, A., Tsintsadze, T., Pankratov, Y., Kopanitsa, M., & Chatterjee, S. S. (2001). Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum. Pharmacopsychiatry 34 Suppl 1, S74-S82.

  12. Tsintsadze, T., Lozovaya, N., & Krishtal, O. (2001). Effects of Long-Term Hypoxia/ Hypoglycemia on Synaptic Transmission between the CA3 and CA1 Zones in Rat Hippocampal Slices. Neurophysiology (Kiev) 33, 365-371.

  13. Fisunov, A., Lozovaya, N., Tsintsadze, T., Chatterjee, S., Noldner, M., & Krishtal, O. (2000). Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons. Pflugers Arch. 440, 427-434.

  14. Kirichok, Y., Boychuk, Y. A., Kopanitsa, M. V., Tsintsadze, T. S., Lozovaya, N. A., & Krishtal, O. A. (2000). Effects of mibefradil on synaptic transmission in the hippocampus and on voltage-dependent currents in isolated hippocampal and thalamic neurons of the rat. Neurophysiology (Kiev) 32, 12-16.

  15. Lozovaya, N. A., Kopanitsa, M. V., Boychuk, Y. A., & Krishtal, O. A. (1999). Enhancement of glutamate release uncovers spillover-mediated transmission by N-methyl-D-aspartate receptors in the rat hippocampus. Neuroscience 91, 1321-1330.

  16. Kopanitsa, M., Boychuk, Y. A., Lozovaya, N. A., & Krishtal, O. A. (1999). Interneuronal cross-talk mediated by transsynaptic diffusion of neurotransmitters. Fisiologichni Zhurnal (in Ukrainian) 45, 132-147.

  17. Kopanitsa, M., Boychuk, Y. A., Lozovaya, N., & Krishtal, O. (1997). Effects of blockers of voltage-operated potassium channels on an NMDA component of excitatory synaptic transmission in the CAI subfield of the rat hippocampus. Neurophysiology (Kiev) 29, 241-244.

  18. Lozovaya, N., Tsintsadze, T., Kopanitsa, M., Boychuk, Y. A., & Krishtal, O. (1997). Increased contribution of NMDA-receptors to synaptic transmission in CA1 area of the rat hippocampus after short-term episodes of hypoxia/aglycaemia. Neurophysiology (Kiev) 29, 4-9.

  19. Tsintsadze, T., Lozovaya, N., Klishin, A., & Krishtal, O. (1996). NMDA receptor-mediated synapses between CA1 neurones: activation by ischaemia. Neuroreport 7, 2679-2682.

  20. Klishin, A., Tsintsadze, T., Lozovaya, N., & Krishtal, O. (1995). Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca(2+)-dependent activation by blocking A1 adenosine receptors. Proc.Natl.Acad.Sci.U.S.A 92, 12431-12435. [full text]

  21. Lozovaya, N. A. & Klee, M. R. (1995). Phorbol diacetate differentially regulates the N-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated components of the rat hippocampal excitatory postsynaptic currents. Neurosci.Lett. 189, 101-104.

  22. Klishin, A., Lozovaya, N., & Krishtal, O. (1995). A1 adenosine receptors differentially regulate the N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated components of hippocampal excitatory postsynaptic current in a Ca2+/Mg(2+)-dependent manner. Neuroscience 65, 947-953.

  23. Klishin, A., Lozovaya, N., & Krishtal, O. (1994). Persistently enhanced ratio of NMDA and non-NMDA components of rat hippocampal EPSC after block of A1 adenosine receptors at increased [Ca2+]o/[Mg2+]o. Neurosci.Lett. 179, 132-136.

  24. Klishin, A., Lozovaya, N., Pintor, J., Miras-Portugal, M. T., & Krishtal, O. (1994). Possible functional role of diadenosine polyphosphates: negative feedback for excitation in hippocampus. Neuroscience 58, 235-236.

  25. Klishin, A., Lozovaya, N., & Krishtal, O. (1994). Modulation by diadenosine polyphosphates of synaptic transmission in the hippocampus. Neurophysiology (Kiev) 26, 347-349.

  26. Lozovaya, N. A., Vulfius, C. A., & Ilyin, V. I. (1993). Intracellular ATP modulates desensitization of acetylcholine receptors controlling chloride current in Lymnaea neurons. Pflugers Arch. 424, 385-390.

  27. Lozovaya, N. A., Vulfius, C. A., Ilyin, V. I., & Krasts, I. V. (1993). Intracellular ATP modifies the voltage dependence of the fast transient outward K+ current in Lymnaea stagnalis neurones. J.Physiol 464, 441-455.

  28. Erdelyi, L., Ilyin, V. I., Lozovaya, N. A., & Vulfius, C. A. (1990). Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons. Neurosci.Lett. 117, 99-104.

  29. Lozovaya, N., Vulfius, C. A., Ilyin, V. I., & Krasts, I. V. (1990). Kinetics of desensitisation of the nicotinic acetycholine receptors is determinate by intracellular ATP content. Docl.Acad.Nauk, SSSR (in Russian) 315, 741-744.

  30. Lozovaya, N. A., Vulfius, C. A., Ilyin, V. I., & Krasts, I. V. (1990). Intracellular ATP modulates voltage-dependence of fast transient potassium currents in molluscan neuron membrane. Biologicheskie Membrany (Russia) 7, 198-204.

  31. Lozovaya, N. A., Vulfius, C. A., Erdelyi, L., & Ilyin, V. I. (1990). Modulatory effect of intracellular magnesium on fast transient potassium currents in molluscan neuron membrane. Biologicheskie Membrany (Russia) 7, 198-204.