- What single scientific paper or talk changed your career path?
- The Nobel prize winning papers by Alan Hodgkin and Andrew Huxley.


  1. Kondratskaya,E.L., Pankratov,Y.V., Lalo,U.V., Chatterjee,S.S., and Krishtal,O.A. (2004). Inhibition of hippocampal UP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. Neurochemistry International 44, 171-177.
  2. Pankratov,Y.V. and Krishtal,O.A. (2003). Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: Implication of glutamate spillover and receptor saturation. Biophysical Journal 85, 3375-3387.
  3. Chatterjee,S.S., Kondratskaya,E.L., and Krishtal,O.A. (2003). Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. Pharmacopsychiatry 36, S68-S77.
  4. Kopanitsa,M.V., Yakubovska,L.M., Rudenko,O.P., and Krishtal,O.A. (2002). Modulation of GABA(A) receptor-mediated currents by benzophenone derivatives in isolated rat Purkinje neurones. Neuropharmacology 43, 764-777.
  5. Pankratov,Y.V., Lalo,U.V., and Krishtal,O.A. (2002). Role for P2X receptors in long-term potentiation. Journal of Neuroscience 22, 8363-8369.
  6. Pankratov,Y., Lalo,U., Krishtal,O., and Verkhratsky,A. (2002). Ionotropic P2X purinoreceptors mediate synaptic transmission in rat pyramidal neurones of layer II/III of somato-sensory cortex. Journal of Physiology-London 542, 529-536.
  7. Tsintsadze,T.S., Lozovaya,N.A., and Krishtal,O.A. (2001). Effects of long-term hypoxia/hypoglycemia on synaptic transmission between the CA3 and CA1 zones in rat hippocampal slices. Neurophysiology 33, 365-371.
  8. Kondratskaya,E.L., Lishko,P.V., Chatterjee,S.S., and Krishtal,O.A. (2002). BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel. Neurochemistry International 40, 647-653.
  9. Maximyuk,O.P., Lozovaya,N.A., Kopanitsa,M.V., and Krishtal,O.A. (2002). G-protein inhibition of N- and P/Q-type calcium channels. Biologicheskie Membrany 19, 42-48.
  10. Fisyunov,A.I., Lozovaya,N.A., Tsyntsadze,T.S., Yatsenko,N.M., Chatterjee,S., and Krishtal,O.A. (2001). Modulating action of hyperforin on the P-type calcium channels in the membranes of rat cerebellar purkinje neurons. Neurophysiology 33, 5-10.
  11. Pankratov,Y.V., Lalo,U.V., Dashkin,A.N., and Krishtal,O.A. (2001). Heterogeneity of the functional expression of P2X3 and P2X2/3 receptors in the primary nociceptive neurons of rat. Neurochemical Research 26, 993-1000.
  12. Krishtal,O., Lozovaya,N., Fisunov,A., Tsintsadze,T., Pankratov,Y., Kopanitsa,M., and Chatterjee,S.S. (2001). Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum. Pharmacopsychiatry 34, S74-S82.
  13. Kopanitsa,M.V., Zhuk,O.V., Zinkovsky,V.G., and Krishtal,O.A. (2001). Modulation of GABA(A) receptor-mediated currents by phenazepam and its metabolites. Naunyn-Schmiedebergs Archives of Pharmacology 364, 1-8.
  14. Lalo,U.V., Pankratov,Y.V., Arndts,D., and Krishtal,O.A. (2001). Omega-Conotoxin GVIA potently inhibits the currents mediated by P2X receptors in rat DRG neurons. Brain Research Bulletin 54, 507-512.
  15. Ostrovskaya,O.I., Kostyuchenko,O.V., and Krishtal,O.A. (2000). A component of the transmembrane current in molluscan neurons is gated by both protons and voltage. Neurophysiology 32, 125-126.
  16. Kopanitsa,M.V., Zbarska,S.M., Boychuk,Y.A., and Krishtal,O.A. (2000). Modulation of GABA-activated currents by phenazepam and its metabolites in isolated rat Purkinje neurons. Neurophysiology 32, 192.
  17. Krishtal,O., Kirichok,Y., Tsintsadze,T., Lozovaya,N., Loesel,W., and Arndts,D. (2001). New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons. Neuropharmacology 40, 233-241.
  18. Gerasimov,V.D., Artemenko,D.P., and Krishtal,O.A. (2001). Preconditioning by motor activity protects rat hippocampal CA1 neurons against prolonged ischemia. Brain Research 888, 326-329.
  19. Kirichok,Y.V., Boychuk,Y.A., Kopanitsa,M.V., Tsintsadze,T.S., Lozovaya,N.A., and Krishtal,O.A. (2000). Effects of mibefradil on synaptic transmission in the hippocampus and on voltage-dependent currents in isolated hippocampal and thalamic neurons of the rat. Neurophysiology 32, 12-16.
  20. Fisunov,A., Lozovaya,N., Tsintsadze,T., Chatterjee,S., Noldner,M., and Krishtal,O. (2000). Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons. Pflugers Archiv-European Journal of Physiology 440, 427-434.
  21. Zhenochin,S.P., Piotrovsky,L.B., Dumpis,M.A., Maximyuk,O.P., Lishko,P.V., Tsyndrenko,A.Y., and Krishtal,O.A. (1999). Analogs of a superacidic NMDA receptor agonist, N-phthalamoyl- L-glutamic acid (PhGA): Activity and mode of interaction with the receptor recognition site. Neurophysiology 31, 295-303.
  22. Artemenko,D.P., Gerasimov,V.D., and Krishtal,O.A. (2000). Electrical responses in hippocampal slices after prolonged global ischemia: effects of neuroprotectors. Brain Research 863, 66-70.
  23. Kopanitsa,M.V., Krishtal,O.A., and Komissarov,I.V. (2000). Inhibitory action of ambocarb on voltage-operated sodium channels in rat isolated hippocampal pyramidal neurons. Clinical and Experimental Pharmacology and Physiology 27, 46-54.
  24. Lishko,P.V., Piotrovsky,L.B., Maksimyuk,A.P., and Krishtal,O.A. (1999). Dependence of pharmacological activity of new NMDA agonists and antagonists on their chemical structure. Neurophysiology 31, 147-149.
  25. Filippov,V.M. and Krishtal,O.A. (1999). Pharmacological properties of the potassium-activated inward current in pyramidal hippocampal neurons. Neurophysiology 31, 49-52.
  26. Chatterjee,S., Filippov,V., Lishko,P., Maximyuk,O., Noldner,M., and Krishtal,O. (1999). Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat. Life Sciences 65, 2395-2405.
  27. Magura,E.I., Krishtal,O.A., and Gleitz,J. (1998). Effects of (+)-methysticin on the mechanisms responsible for sodium channel inactivation in rat hippocampal neurons. Neurophysiology 30, 256-258.
  28. Filippov,V.M., Pinchenko,V., Volkova,T.M., and Krishtal,O.A. (1998). Membrane responses to changes in the extracellular potassium concentration in isolated hippocampal pyramidal neurons. Neurophysiology 30, 259-263.
  29. Fisyunov,A.I. and Krishtal,O.A. (1998). Kinetic characteristics of interaction of conotoxin with N-type Ca2+ channels in rat hippocampal neurons. Neurophysiology 30, 285-288.
  30. Filippov,V. and Krishtal,O. (1999). The mechanism gated by external potassium and sodium controls the resting conductance ln hippocampal and cortical neurons. Neuroscience 92, 1231-1242.
  31. Lozovaya,N.A., Kopanitsa,M.V., Boychuk,Y.A., and Krishtal,O.A. (1999). Enhancement of glutamate release uncovers spillover-mediated transmission by N-methyl-D-aspartate receptors in the rat hippocampus. Neuroscience 91, 1321-1330.
  32. Lishko,P.V., Maximyuk,O.P., Chatterjee,S.S., Noldner,M., and Krishtal,O.A. (1998). The putative cognitive enhancer KA-672.HCl is an uncompetitive voltage-dependent NMDA receptor antagonist. Neuroreport 9, 4193-4197.
  33. Pankratov,Y., Castro,E., Miras-Portugal,M.T., and Krishtal,O. (1998). A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus. European Journal of Neuroscience 10, 3898-3902.
  34. Kopanitsa,M.V., Lozovaya,N.A., Boychuk,Y.A., and Krishtal,O.A. (1997). Effects of blockers of voltage-operated potassium channels on an NMDA component of excitatory synaptic transmission in the CAI subfield of the rat hippocampus. Neurophysiology 29, 241-244.
  35. Kirichok,Y.V., Nikolaev,A.V., and Krishtal,O.A. (1998). [K+](out) accelerates inactivation of Shal-channels responsible for A-current in rat CA1 neurons. Neuroreport 9, 625-629.
  36. Magura,E.I., Kopanitsa,M.V., Gleitz,J., Peters,T., and Krishtal,O.A. (1997). Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na+-channels in rat CA1 hippocampal neurons. Neuroscience 81, 345-351.
  37. Tsintsadze,T., Lozovaya,N., Klishin,A., and Krishtal,O. (1996). NMDA receptor-mediated synapses between CA1 neurones: Activation by ischaemia. Neuroreport 7, 2679-2682.
  38. Parsons,C.G., Panchenko,V.A., Pinchenko,V.O., Tsyndrenko,A.Y., and Krishtal,O.A. (1996). Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. European Journal of Neuroscience 8, 446-454.
  39. Panchenko,V.A., Pintor,J., Tsyndrenko,A.Y., MirasPortugal,M.T., and Krishtal,O.A. (1994). Modulatory effects of diadenosine polyphosphates on different types of calcium channels in the rat central neurons. Neurophysiology 26, 334-340.
  40. Klishin,A.I., Lozovaya,N.A., and Krishtal,O.A. (1994). Modulation by diadenosine polyphosphates of synaptic transmission in the hippocampus. Neurophysiology 26, 347-349.
  41. Kopanitsa,M.V., Panchenko,V.A., Magura,E.I., Lishko,P.V., and Krishtal,O.A. (1995). Capsaicin blocks Ca2+ channels in isolated rat trigeminal and hippocampal neurones. Neuroreport 6, 2338-2340.
  42. Klishin,A., Tsintsadze,T., Lozovaya,N., and Krishtal,O. (1995). Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca2+-dependent activation by blocking A(1) adenosine receptors. Proceedings of the National Academy of Sciences of the United States of America 92, 12431-12435.
  43. Panchenko,V.A., Pintor,J., Tsyndrenko,A.Y., MirasPortugal,M.T., and Krishtal,O.A. (1996). Diadenosine polyphosphates selectively potentiate N-type Ca2+ channels in rat central neurons. Neuroscience 70, 353-360.
  44. Klishin,A., Lozovaya,N., and Krishtal,O. (1995). A (1) adenosine receptors differentially regulate the N-methyl- D-aspartate and non-N-methyl-D-aspartate receptor-mediated components of hippocampal excitatory postsynaptic current in a Ca2+/Mg2+-dependent manner. Neuroscience 65, 947-953.
  45. Klishin,A., Lozovaya,N., and Krishtal,O. (1994). Persistently enhanced ratio of NMDA and non-NMDA components of rat hippocampal EPSC after block of A(1) adenosine receptors at increased [Ca2+](o) [Mg2+](o). Neuroscience Letters 179, 132-136.
  46. Klishin,A., Lozovaya,N., Pintor,J., MirasPortugal,M.T., and Krishtal,O. (1994). Possible functional-role of diadenosine polyphosphates - negative feedback for excitation in hippocampus. Neuroscience 58, 235-236.
  47. Kiskin,N.I., Chizhmakov,I.V., Tsyndrenko,A.Y., Krishtal,O.A., and Tegtmeier,F. (1993). R56865 and flunarizine as Na+-channel blockers in isolated Purkinje neurons of rat cerebellum. Neuroscience 54, 575-585.
  48. Panchenko,V.A., Krishtal,O.A., Tegtmeier,F., and Tsyndrenko,A.Y. (1993). R56865 as Ca2+-channel blocker in Purkinje neurons of rat - comparison with flunarizine and nimodipine. Neuroscience 54, 587-594.
  49. Garaschuk,O., Kovalchuk,Y., and Krishtal,O. (1993). Glutamate and theta-rhythm stimulation selectively enhance NMDA component of EPSC in CA1 neurons of young-rats. Neuroscience Letters 151, 29-32.
  50. Kiskin,N.I., Chizhmakov,I.V., Tsyndrenko,A.Y., Mueller,A.L., Jackson,H., and Krishtal,O.A. (1992). A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the agelenopsis-aperta spider. Neuroscience 51, 11-18.
  51. Chizhmakov,I.V., Kiskin,N.I., and Krishtal,O.A. (1992). 2 types of steady-state desensitization of N-methyl-D-aspartate receptor in isolated hippocampal neurons of rat. Journal of Physiology-London 448, 453-472.
  52. Garaschuk,O., Kovalchuk,Y., and Krishtal,O. (1992). Adenosine-dependent enhancement by methylxanthines of excitatory synaptic transmission in hippocampus of rats. Neuroscience Letters 135, 10-12.
  53. Krishtal,O.A., Chernevskaya,N.I., and Obukhov,A.G. (1991). Inhibitory-action of NMDA-type receptors on N-type Ca-channels in hippocampal neurons. Biomedical Research-Tokyo 12, 67-69.
  54. Kiskin,N.I., Tsyndrenko,A.Y., Dumpis,M.A., Piotrovsky,L.B., and Krishtal,O.A. (1991). A novel selective NMDA agonist, N-phthalamoyl-L-glutamic acid (PHGA). Neuroreport 2, 29-32.
  55. Chernevskaya,N.I., Obukhov,A.G., and Krishtal,O.A. (1991). NMDA receptor agonists selectively block N-type calcium channels in hippocampal neurons. Nature 349, 418-420.
  56. Kovalchuk,Y.N., Krishtal,O.A., and Nowycky,M.C. (1990). The proton-activated inward current of rat sensory neurons includes a calcium component. Neuroscience Letters 115, 237-242.
  57. Kiskin,N.I., Krishtal,O.A., and Tsyndrenko,A.Y. (1990). Cross-desensitization reveals pharmacological specificity of excitatory amino-acid receptors in isolated hippocampal neurons. European Journal of Neuroscience 2, 461-470.
  58. Akaike,N., Krishtal,O.A., and Maruyama,T. (1990). Proton-induced sodium current in frog isolated dorsal root ganglion cells. Journal of Neurophysiology 63, 805-813.
  59. Chizhmakov,I.V., Kiskin,N.I., Tsyndrenko,A.Y., and Krishtal,O.A. (1990). Desensitization of NMDA receptors does not proceed in the presence of kynurenate. Neuroscience Letters 108, 88-92.
  60. Krishtal,O.A., Petrov,A.V., Smirnov,S.V., and Nowycky,M.C. (1989). Hippocampal synaptic plasticity induced by excitatory amino- acids includes changes in sensitivity to the calcium-channel blocker, omega-conotoxin. Neuroscience Letters 102, 197-204.
  61. Chizhmakov,I.V., Kiskin,N.I., Krishtal,O.A., and Tsyndrenko,A.Y. (1989). Glycine action on N-methyl-D-aspartate receptors in rat hippocampal neurons. Neuroscience Letters 99, 131-136.
  62. Krishtal,O.A., Marchenko,S.M., and Obukhov,A.G. (1988). Cationic channels activated by extracellular ATP in rat sensory neurons. Neuroscience 27, 995-1000.
  63. Krishtal,O.A., Marchenko,S.M., Obukhov,A.G., and Volkova,T.M. (1988). Receptors for ATP in rat sensory neurons - the structure-function relationship for ligands. British Journal of Pharmacology 95, 1057-1062.
  64. Akaike,N., Kaneda,M., Hori,N., and Krishtal,O.A. (1988). Blockade of N-methyl-D-aspartate response in enzyme-treated rat hippocampal neurons. Neuroscience Letters 87, 75-79.
  65. Krishtal,O.A., Smirnov,S.V., and Osipchuk,Y.V. (1988). Changes in the state of the excitatory synaptic system in the hippocampus on prolonged exposure to excitatory amino-acids and antagonists. Neuroscience Letters 85, 82-88.
  66. Krishtal,O.A., Osipchuk,Y.V., and Vrublevsky,S.V. (1988). Properties of glycine-activated conductances in rat-brain neurons. Neuroscience Letters 84, 271-276.
  67. Krishtal,O.A., Osipchuk,Y.V., Shelest,T.N., and Smirnoff,S.V. (1987). Rapid extracellular pH transients related to synaptic transmission in rat hippocampal slices. Brain Research 436, 352-356.
  68. Kiskin,N.I., Krishtal,O.A., Tsyndrenko,A.Y., Mandelshtam,Y.E., Baranov,G.M., and Dejko,L.M. (1987). Modifying action of L-glutamate esters on the excitatory amino-acid receptors in the membrane of hippocampal neurons. Biologicheskie Membrany 4, 937-946.
  69. Akaike,N., Kawai,N., Kiskin,N.I., Kljuchko,E.M., Krishtal,O.A., and Tsyndrenko,A.Y. (1987). Spider toxin blocks excitatory amino-acid responses in isolated hippocampal pyramidal neurons. Neuroscience Letters 79, 326-330.
  70. Marchenko,S.M., Krishtal,O.A., Slepushkin,V.A., and Bukrinskaya,A.G. (1987). Virus-induced changes in cell membrane conductivity. 2. Comparative analysis of influenza and sendai virus-induced increase of different cell membrane conductivity and pH influence on this process. Biologicheskie Membrany 4, 747-755.
  71. Slepushkin,V.A., Bukrinskaya,A.G., Marchenko,S.M., Volkova,T.M., and Krishtal,O.A. (1987). Virus-induced changes in cell membrane conductivity. 1. Sendai virus-induced conductivity changes of cytoplasmic membranes of cultured monkey kidney cells. Biologicheskie Membrany 4, 486-494.
  72. Akaike,N., Inoue,M., and Krishtal,O.A. (1986). Concentration-clamp study of gamma-aminobutyric-acid-induced chloride current kinetics in frog sensory neurons. Journal of Physiology-London 379, 171-185.
  73. Kiskin,N.I., Krishtal,O.A., and Tsyndrenko,A.Y. (1986). Excitatory amino-acid receptors in the membrane of hippocampal pyramidal neurons. Biologicheskie Membrany 3, 909-919.
  74. Kiskin,N.I., Krishtal,O.A., Tsyndrenko,A.Y., and Akaike,N. (1986). Are sulfhydryl-groups essential for function of the glutamate-operated receptor ionophore complex? Neuroscience Letters 66, 305-310.
  75. Krishtal,O.A. and Marchenko,S.M. (1986). Pharmacological properties of the receptor for ATP in the sensory neurons of rats. Biomedical Research-Tokyo 7, 79-81.
  76. Kiskin,N.I., Krishtal,O.A., and Tsyndrenko,A.Y. (1986). Excitatory amino-acid receptors in hippocampal neurons - kainate fails to desensitize them. Neuroscience Letters 63, 225-230.
  77. Krishtal,O.A., Marchenko,S.M., and Pidoplichko,V.I. (1983). Receptor for ATP in the membrane of mammalian sensory neurons. Neuroscience Letters 35, 41-45.
  78. Krishtal,O.A. and Pidoplichko,V.I. (1981). A receptor for protons in the membrane of sensory neurons may participate in nociception. Neuroscience 6, 2599-2601.
  79. Krishtal,O.A. and Pidoplichko,V.I. (1981). A receptor for protons in small neurons of trigeminal ganglia - possible role in nociception. Neuroscience Letters 24, 243-246.
  80. Kostyuk,P.G., Krishtal,O.A., and Pidoplichko,V.I. (1981). Calcium inward current and related charge movements in the membrane of snail neurons. Journal of Physiology-London 310, 403-421.
  81. Krishtal,O.A., Pidoplichko,V.I., and Shakhovalov,Y.A. (1981). Conductance of the calcium-channel in the membrane of snail neurons. Journal of Physiology-London 310, 423-434.
  82. Krishtal,O.A. and Pidoplichko,V.I. (1980). A receptor for protons in the nerve cell membrane. Neuroscience 5, 2325-2327.
  83. Kostyuk,P.G., Krishtal,O.A., and Pidoplichko,V.I. (1980). Gating current of calcium channels in the neuronal membrane. Bioelectrochemistry and Bioenergetics 7, 421-431.
Curriculum Vitae | Lab Research | Department

Updated on January 31, 2003.
Send comments to webmaster.